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СОЛИ РАЛЬТЕГРАВИРА И ИХ КРИСТАЛЛИЧЕСКИЕ ФОРМЫ
专利权人:
ТЕВА ФАРМАСЬЮТИКАЛ ИНДАСТРИЗ ЛТД.
发明人:
КВОКАЛ Ана,ХЕДВАТИ Лилах,БЕРШТЕЙН Ревитал,ЙЕОРИ Ади,МОШКОВИЦ-КАПЦАН Ринат
申请号:
RU2012146517
公开号:
RU2012146517A
申请日:
2011.04.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Crystalline form V Raltegravira kaliya.2. Raltegravira potassium crystalline form according to claim 1, characterized by data selected from: a powder X-ray diffraction having peaks at 8.0, 11.9, 18.2 and 26.6 degrees 2 theta ± 0,2 degrees 2 theta Powder X-ray diffraction, essentially such as shown in Figure 2 C-NMR spectrum of the solid forms of the signals at 121.9, 144.0, 149.3 and 170.3 ± 0.2 ppm C solid NMR spectrum of shape having a chemical shift difference between the signal exhibiting the lowest chemical shift and another in the chemical shift range of 100 to 180 ppm 111.9, 134.0, 139.3 and 160.3 ± 0.1 ppm C-NMR spectrum of the solid form is substantially the same as shown in Figure 31 and sochetaniyami.3. Raltegravir crystalline potassium of claim 2, further characterized by data selected from: X-ray powder having additional peaks at 14.9, 19.8, 24.9, 27.7 and 28.9 degrees 2 theta degrees 2 ± 0,2 theta DSC thermogram, such as depicted in Figure 29 The TGA thermogram of such as shown in Figure 30 Fourier-Raman spectrum, such as that shown in Figure 32 and sochetaniyami.4. Crystalline Form IV Raltegravira kaliya.5. The crystalline form of potassium Raltegravira according to claim 4, characterized by data selected from: a powder X-ray diffraction having peaks at 6.5, 7.5, 8.1, 18.4 and 23.2 degrees 2 theta ± 0,2 degrees 2 theta Powder X-ray diffraction, essentially such as shown in Figure 1 and sochetaniyami.6. Crystalline potassium Raltegravir according to claim 5, further characterized by data selected from: X-ray powder having additional peaks at 13.0, 17.5, 24.2 and 25.5 degrees 2 theta ± 0,2 degrees 2 theta DSC thermogram, such as shown in Figure 27 The TGA thermogram of such as1. Кристаллическая форма V Ральтегравира калия.2. Кристаллическая форма Ральтегравира калия по п.1, характеризуемая данными, выбранными из: порошковой рентгенограммы, имеющей пики при 8,0, 11,9, 18,2 и 26,6 градусах 2 тета ± 0,2 градуса 2 тета порошковой рентгенограммы, по суще
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