MODULATION DE LA VITESSE DE LIBERATION DE MEDICAMENTS EN CONTROLANT LA TRANSITION DU PH DANS DES HYDROGELS

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专利权人:

CONFLUENT SURGICAL; INC.

发明人:

BLASKOVICH, PHILLIP,OHRI, RACHIT,COSTA, DANIEL S.

申请号：

CA2730598

公开号：

CA2730598C

申请日:

2011.02.03

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.

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