Modulating drug release rate by controlling the kinetics of the pH transition in hydrogels

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专利权人:

Confluent Surgical; Inc.

发明人:

Blaskovich, Philip,Ohri, Rachit,Costa, Daniel S.

申请号：

AU2011201184

公开号：

AU2011201184B2

申请日:

2011.03.16

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2011201184B220140703.pdf#####MODULATING DRUG RELEASE RATE BY CONTROLLING THE KINETICS OF THE PH TRANSITION IN HYDROGELS Abstract 5 Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which io the hydrogel is placed.

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