Liansheng Li,Jun Feng,Tao Wu,Pingda Ren,Yi Liu,Yuan Liu,Yun Oliver Long
申请号：
US15805716
公开号：
US10370386B2
申请日:
2017.11.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I):or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
