A P2X4 receptor antagonist such as paroxetine or a diazepinedione derivative represented by the following general formula (IX) is used as a prophylactic or therapeutic agent for acute pain of shingles-related pain. (Wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, etc., R4 and R5 represent a hydrogen atom and the like, W represents a 5- or 6-membered heterocyclic ring containing 1 to 4 nitrogen atoms as a ring constituent element which may have a substituent.パロキセチンや次の一般式（ＩＸ）で表されるジアゼピンジオン誘導体等のＰ２Ｘ４受容体拮抗剤を帯状疱疹関連痛の急性期疼痛の予防又は治療剤として使用する。（式中、Ｒ１は水素原子、炭素数１～８のアルキル基他を表し、Ｒ２及びＲ３は水素原子、炭素数１～８のアルキル基等を表し、Ｒ４及びＲ５は水素原子他を表し、そして、Ｗは置換基を有していても良い環構成元素として窒素原子を１～４個含む５又は６員環の複素環を表す。）
