This invention includes the dosage of ranorajin of the remedy effective quantity, it regards the method for CNS obstacle such as the epilepsy and one headache. With feature of portion of this invention, as for ranorajin, it is prescribed for remedying or prevention the CNS obstacle which it is related to SCN1A mutation. The thermal characteristic spasm plus the general epileptic (GEFS+) 2 types which are accompanied, the infant critical fairway clo knee epilepsy (SMEI), family characteristic one paralysis characteristic one headache 3 type (FHM3), the thermal characteristic spasm plus you can list to a state where it is related to the mutation in SCN1A, the general epileptic (GEFS+) 1 types which are accompanied, but it is not limited in these.本発明は、治療的有効量のラノラジンの投与を含む、癲癇および片頭痛などのCNS障害のための方法に関する。本発明の一部の態様では、ラノラジンは、SCN1A変異に関連するCNS障害の治療または予防のために投与される。SCN1Aにおける変異に関連する状態には、熱性痙攣プラスを伴う全般癲癇(GEFS+)2型、乳児重症ミオクロニー癲癇(SMEI)、家族性片麻痺性片頭痛3型(FHM3)、熱性痙攣プラスを伴う全般癲癇(GEFS+)1型が挙げられるが、これらに限定されない。
