This invention at least designates 1 where it is chosen kinds as the active ingredient from the group which consists of tetorahidoroisoaruhua acid, roisoaruhua acid and hekisahidoroisoaruhua acid, the new bone absorption inhibiter is offered. In addition as for this invention, the medicine and the eating and drinking item additive which contain that kind of bone absorption inhibiter, the eating and drinking item, the fodder additive and the fodder etc are offered.本発明は、テトラヒドロイソアルファ酸、ローイソアルファ酸及びヘキサヒドロイソアルファ酸からなる群より選ばれる少なくとも1種を有効成分とする、新規の骨吸収抑制剤を提供する。本発明はまた、そのような骨吸収抑制剤を含有する医薬、飲食品添加物、飲食品、飼料添加物、飼料等を提供する。