The present invention relates to substituted benzene compounds comprising compounds of Formula II: (II) and compounds of Formula III: (III) and compounds of Formula VI: (VI) and compounds of Formula VII: (VII) Such compounds may be useful as EZH2 inhibitors. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.