The General Hospital Corporation;Dana-Farber Cancer Institute, Inc.
发明人:
David E. Fisher,Nisma Mujahid,Ryo Murakami,Nathanael S. Gray,Yanke Liang,Hwan Geun Choi
申请号：
US16489462
公开号：
US20200253981A1
申请日:
2018.02.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (VII). Also provided are pharmaceutical compositions, methods, and uses that include or involve a compound described herein.
