GAETANO BRAMBILLA,ROBERT JOHNSON,DAVID ANDREW LEWIS
申请号：
ARP130103062
公开号：
AR092274A1
申请日:
2013.08.28
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
An Actuator of an aerosol inhalation Device comprising a Housing which is adapted to receive an aerosol Container which contains a pressurized Drug formulation, a portion of The Conduit through which the user inhales,A Nozzle and a Hole which is characterized by the presence of a tubular Element extends in the portion of The Conduit from the Orifice opening in a longitudinal axis is aligned with a longitudinal Axis of The Conduit portion. In particular, Said tubular element is positioned to enclose the Orifice Opening inside a Cavity.The tubular element is configured such that a terminal of their Openings can have a tight fit with the external surface of the nozzle around the Orifice opening to be in a continuous Flow path with the hole.Among the advantages of this Actuator is the significant reduction of the Coarse fraction of the non respirable aerosol Medicine issued by the Inertial Impact and Retention in the Actuator in the oropharynx only minor side effects associated with the resulting And oral candidiasis in the patient.Furthermore, the presence of the tubular Element and has a negligible impact on the minimum dose of Fine particles and the particle size Distribution (PSD) of particles with an aerodynamic diameter administered to 9 mm.Un actuador de un dispositivo de inhalación de aerosol que comprende un alojamiento que está adaptado para recibir un recipiente de aerosol que contiene una formulación de medicamento presurizada, una porción de conducto a través de la cual inhala el usuario, un conjunto de boquilla y un orificio que se caracteriza por la presencia de un elemento tubular que se extiende en la porción de conducto desde la abertura del orificio en un eje longitudinal que está alineado con un eje longitudinal de la porción de conducto. En particular, dicho elemento tubular está posicionado para encerrar la abertura del orificio dentro de una cavidad. El elemento tubular está configurado de modo tal que una de sus aberturas terminales puede tener u
