A NOVEL ROLE FOR TERMINAL RNA URIDYLATION AND RNA TURNOVER IN ONCOGENESIS

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专利权人:

Children's Medical Center Corporation

发明人:

George Q. Daley,Kaloyan Tsanov,Daniel S. Pearson

申请号：

US16308196

公开号：

US20190300885A1

申请日:

2017.06.07

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Described herein is a LIN28-independent role of TUTases in oncogenesis. Provided herein are compositions and methods for treating cancer via inhibition of TUTases. TUTase depletion also sensitizes the cells to disruptions in RNA metabolism and/or protein metabolism. Thus, further provided herein are strategies of combination therapy, combining TUTase inhibitors, agents that disrupt RNA metabolism, and agents that disrupt protein metabolism, to treat cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/