DALEY, George, Q.,TSANOV, Kaloyan,PEARSON, Daniel, S.
申请号：
EP17810978
公开号：
EP3464382A4
申请日:
2017.06.07
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Described herein is a LIN28-independent role of TUTases in oncogenesis. Provided herein are compositions and methods for treating cancer via inhibition of TUTases. TUTase depletion also sensitizes the cells to disruptions in RNA metabolism and/or protein metabolism. Thus, further provided herein are strategies of combination therapy, combining TUTase inhibitors, agents that disrupt RNA metabolism, and agents that disrupt protein metabolism, to treat cancer.
