SASS, PHILIP M.,NICOLAIDES, NICHOLAS,GRASSO, LUIGI,ROUTHIER, ERIC,GU, WEI,YOUNG, JASON,YAO, JUN
申请号：
CA2815080
公开号：
CA2815080A1
申请日:
2011.10.19
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti- FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an anti-FRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention.
