NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
发明人:
Varda SHOSHAN-BARMATZ,Arie LEV GRUZMAN
申请号：
US16672731
公开号：
US20200115348A1
申请日:
2019.11.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.
