Bruce A. Sullenger,Kady-Ann C. Steen-Burrell,Bethany Powell Gray
申请号：
US15570065
公开号：
US20180117182A1
申请日:
2016.04.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
