The present invention is a composition and method for treating diseases and disorders associated with an immature stop codon (PTC), which comprises or encodes an anticodon editing (ACE) tRNA (ACE-tRNA). Provided are methods that include administration of nucleic acid molecules. Specifically, the method comprises administering to the subject at least one ACE-tRNA specific for UGA, UAA, or UAG to treat the associated disorder. In addition, the nucleic acid sequence of ACE-tRNA is disclosed.
