可誘導性結合蛋白和使用方法农业专利-农业学术服务平台

发明人:: BAEUERLE, PATRICK,博伊尔勒　派翠克,博伊爾勒　派翠克,DUBRIDGE, ROBERT B.,杜布瑞基　罗伯特,杜布瑞基　羅伯特,WESCHE, HOLGER,韦舍　霍尔格,韋舍　霍爾格,EVNIN, LUKE,伊伏宁　卢克,伊伏寧　盧克,GUENOT, JEANMARIE,盖诺　吉恩玛丽,蓋諾　吉恩瑪麗,PANCHAL, ANAND,潘卡尔　阿南德,潘卡爾　阿南德,VINOGR,博伊尔勒派翠克,博伊爾勒派翠克,杜布瑞基罗伯特,杜布瑞基羅伯特,韦舍霍尔格,韋舍霍爾格,伊伏宁卢克,伊伏寧盧克,盖诺吉恩玛丽,蓋諾吉恩瑪麗,潘卡尔阿南德,潘卡爾阿南德

摘要：: Provided herein are conditionally activated polypeptide constructs comprising a protease-activated domain binding to CD3, at least one half-life extension domain, and two or more domains binding to one or more target antigens. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such polypeptide constructs. Also disclosed are methods of using the disclosed polypeptide constructs in the prevention, and/or treatment diseases, conditions and disorders.本發明提供經條件性活化之多肽構建體，該多肽構建體包含與CD3結合之經蛋白酶活化的結構域、至少一個半衰期延長結構域及二或更多個與一或多個靶抗原結合之結構域。亦提供該多肽構建體之醫藥組成物及用於製備該多肽構建體之核酸、重組表現載體和宿主細胞。亦揭示使用該揭示之多肽構建體以預防及/或治療疾病、病症和失調之方法。