Patrick BAEUERLE,Robert B. DUBRIDGE,Holger WESCHE,Luke EVNIN,Jeanmarie GUENOT,Anand PANCHAL,Maia VINOGRADOVA
申请号：
US15727423
公开号：
US20180134789A1
申请日:
2017.10.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are conditionally activated polypeptide constructs comprising a protease-activated domain binding to CD3, at least one half-life extension domain, and two or more domains binding to one or more target antigens. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such polypeptide constructs. Also disclosed are methods of using the disclosed polypeptide constructs in the prevention, and/or treatment diseases, conditions and disorders.
