PROBLEM TO BE SOLVED: To propose a new material allowing vascular endothelial function improvement or nitric oxide production promotion, to provide a vascular endothelial function improving agent allowing further promotion of the nitric oxide production in endothelium-derived relaxation factors, to provide a nitric oxide production promoter, and to provide a food and drink.SOLUTION: There are provided the vascular endothelial function improving agent obtained by formulating a polyphenol derived from grape which is extracted from dregs produced during production of wines with water, ethanol, or water-ethanol with L-arginine as active ingredients nitric oxide production promoter and food and drink.COPYRIGHT: (C)2012,JPO&INPIT【課題】血管内皮機能改善や一酸化窒素産生促進を行える新たな材料を提案するとともに、内皮由来弛緩因子のうち、一酸化窒素産生をさらに促進することのできる血管内皮機能改善剤、一酸化窒素産生促進剤、及び飲食品を提供すること。【解決手段】ブドウ由来のポリフェノールは、ワイン製造時に発生する澱(おり)から水、エタノール、又は水-エタノールにより抽出してなるブドウ由来のポリフェノールと、L-アルギニンとを有効成分として配合して血管内皮機能改善剤、一酸化窒素産生促進剤、及び飲食品を得る。【選択図】なし
