ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人:
Qiang Chen,Ming Yang,Huafang Lai
申请号：
US16617971
公开号：
US20200190525A1
申请日:
2018.05.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to the fields of genetically modified Agrobacterium strains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modified Agrobacterium strains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologics. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.
