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Injectable composition for reducing local fat without pain, edema and side effects and method for producing the same
专利权人:
アミ ファーム カンパニー リミテッド
发明人:
イ、ギ テク
申请号:
JP2019547440
公开号:
JP2020517581A
申请日:
2018.04.20
申请国别(地区):
JP
年份:
2020
代理人:
摘要:
The present invention relates to an injectable composition for local fat reduction free from pain, edema and side effects, and a method for producing the same, more specifically, glycocholic acid (or a salt thereof) or taurocholic acid (or a salt thereof), and phosphatidylcholine ( PPC) in a specific blending ratio, including pain, edema, and necrosis of muscle cells, fibroblasts and vascular endothelial cells in addition to adipocytes, anesthesia at the administration site, extensive swelling, erythema, hardening, and sensation. The present invention relates to an injectable composition for local fat reduction, which is free from side effects such as abnormalities, nodules, pruritus, burning sensation, nerve damage and dysphagia, and a method for producing the composition. A conventional DCA single injection known as a local fat reduction injection, or a PPC injection composition containing a solubilizing agent DCA is used in addition to adipocytes, fibroblasts, vascular endothelial cells and skeletal muscle cells. Necrosis, which is caused by lysis and inevitably, causes pain and side effects such as anesthesia, extensive swelling, local edema, erythema, induration, paresthesia, nodules, pruritus, burning sensation, dysphagia, etc. In addition, while the patient complains of pain, discomfort, and anxiety, and the compliance with medication is low, the injection for topical fat reduction of the present invention has a safe and stable formulation, and lipolysis and An excellent composition that has an excellent effect of selectively inducing cell death (apoptosis) of adipocytes only in adipocytes, does not have the above-mentioned side effects, improves the quality of life of patients, and enhances adherence to medication. Is.本発明は、痛み、浮腫及び副作用がない局所脂肪減少用注射剤組成物とその製造方法に関し、より詳細には、グリココール酸(又はその塩)又はタウロコール酸(又はその塩)、及びホスファチジルコリン(PPC)を特定の配合比で含み、痛み、浮腫、及び、脂肪細胞の他に筋細胞、線維芽細胞及び血管内皮細胞の壊死、投与部位の無感覚症、広範囲の腫れ、紅斑、硬化、感覚異常、結節、掻痒、灼熱感、神経損傷及び嚥下障害などの副作用のない、局所脂肪減少用注射剤組成物と前記組成物の製造方法に関するものである。従来の局所脂肪
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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