TRANSGENIC MOUSE CAPABLE OF SPATIAL AND TEMPORAL CONTROL OF EXPRESSION AND SITE-SPECIFIC MODIFICATION OF TARGET PROTEIN, PRODUCTION METHOD AND USES THEREOF
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
Park Hee-Sung,Yang Aerin
申请号：
US201715695417
公开号：
US2018064076(A1)
申请日:
2017.09.05
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
The present invention relates to a mouse (Mus musculus) in which expression and site-specific modification of a target protein is temporally and spatially controlled, and a method for producing the same and the use thereof, and more particularly to a transgenic mouse in which expression of a target protein having a modification attached to a specific position is temporally and spatially controlled as a result of incorporation of an unnatural amino acid. In the mouse according to the present invention, in which site-specific modification of a target protein is temporally and spatially controllable, expression of the target protein having the site-specific modification attached thereto is controllable depending on the timing and/or position of introduction of an unnatural amino acid. Thus, the mouse according to the present invention is useful for studies on the in vivo functions of cellular proteins, various human diseases including cancers and neurodegenerative disorders, new drug discovery, and the like.
