INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT 0111111010 0111 °nolo III OH Emmo IH Imio oimIE (10) International Publication Number WO 2018/158455 Al (51) International Patent Classification: G01N 33/569 (2006.01) A61K 38/00 (2006.01) (21) International Application Number: PCT/EP2018/055230 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 17159243.9 17159242.1 1703809.2 02 March 2018 (02.03.2018) English English 03 March 2017 (03.03.2017) EP 03 March 2017 (03.03.2017) EP 09 March 2017 (09.03.2017) GB (71) Applicant: TREOS BIO ZRT. [HU/HU]； Viola utca 2, 8200 Veszprem (HU). (72) Inventors: LISZIEWICZ, Julianna； Szorosi ut 13, 8220 Balatonalmadi (HU). MOLNAR, Levente； Kossuth Lajos u. 20., 2363 Felsopakony (HU). TOKE, Eniko； Kossuth Lajos u. 20., 2363 Felsopakony (HU). TOTH, Jozsef； Ujkut u. 72, 9012 Gyor (HU). LORINCZ, Orsolya； Attila u. 27, fszt/13, 1047 Budapest (HU). CSISZOVSZKI, Zsolt； Bik- szadi u. 12/A, 4/9, 1119 Budapest (HU). SOMOGYI, Es- zter； Borgazda u. 3, 8220 Balatonalmadi (HU). PANTYA, Katalin； Ulloi ut 16/b 2.em. 9/b, 1085 Budapest (HU). MEGYESI, Monika； Tancsics Mihaly u. 63, 3441 Mezok- eresztes (HU). (74) Agent: KIMBLIN, Nicola； 14 South Square, Gray's Jim, London Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG
