INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) oviolo VIII VIII VIII 010 Hu Hs (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/013310 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT (51) International Patent Classification: A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61K 9/20 (2006.01) A61K 31/4439 (2006.01) (21) International Application Number: PCT/JP2018/026416 Published: — with international search report (Art 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (22) International Filing Date: 09 July 2018 (09.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 2017-135046 10 July 2017 (10.07.2017) JP (71) Applicant: TAKEDA PHARMACEUTICAL COMPA- NY LIMITED [JP/JP]； 1-1, Doshomachi 4-chome, Chuo- ku, Osaka-shi, Osaka, 5410045 (JP). (72) Inventors: FUJII, Hiroyuki； c/o TAKEDA PHARMA- CEUTICAL COMPANY LIMITED, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). SUZUKI, Akira； c/o TAKEDA CONSUMER HEALTH- CARE COMPANY LIMITED, 17-85, Jusohonmachi 2- chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). (74) Agent: TAKASHIMA, Hajime et al.； Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka, 5410044 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA,
