INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT 0111111010 0111 °nolo III OH Emmo muoi IIII iflo oimIE (10) International Publication Number WO 2018/158456 Al (51) International Patent Classification: A61K 39/00 (2006.01) GO1N 33/569 (2006.01) G01N 33/50 (2006.01) A61K 39/12 (2006.01) (21) International Application Number: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 17159243.9 17159242.1 1703809.2 PCT/EP2018/055231 02 March 2018 (02.03.2018) English English 03 March 2017 (03.03.2017) EP 03 March 2017 (03.03.2017) EP 09 March 2017 (09.03.2017) GB Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) cc 00 O C (71) Applicant: TREOS BIO ZRT [HU/HU]； Viola utca 2, 8200 Veszprem (HU). (72) Inventors: LISZIEWICZ, Julianna； Szorosi ut 13, 8200 Balatonalmadi (HU). MOLNAR, Levente； Kossuth Lajos u. 20., Felsopakony 2363 (HU). TOKE, Eniko, R.； Kos- suth Lajos u. 20., Felsopakony 2363 (HU). TOTH, Jozsef； Ujkut u. 72, 9012 Gyor (HU). LORINCZ, Orsolya； At- tila u. 27, fszt/13, 1047 Budapest (HU). CSISZOVSZKI, Zsolt； Attila u. 27, fszt/13, 1047 Budapest (HU). SOM- OGYI, Eszter； Borgazda u. 3, 8220 Balatonalmadi (HU). PANTYA, Katalin； Ulloi ut 16/b 2.em. 9/b, Budapest 1085 (HU). MEGYESI, Monika； Tancsics Mihaly u. 63, 3441 Mezokeresztes (HU). (74) Agent: KIMBLIN, Nicola； 14 South Square, Gray's Jim, London Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH,
