Edgar L. Hull, Jr.,Rodell Barrientos,Narashima Murthy,Sridhara Am
申请号：
US16768230
公开号：
US20200281881A1
申请日:
2018.11.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are nutritional, or therapeutic, compositions and methods of use in primarily treating kidney patients suffering from low serum albumin. The compositions are divided into four formulations, comprising: 1) the magnesium salt and/or the calcium salt of the alpha keto acids of: α-leucine, α-valine, α-isoleucine, α-phenylalanine, α-hydroxy methionine； and/or α-tryptophan, and/or α-tyrosine； 2) L-lysine monoacetate, L-threonine； and/or 3) histidine, tryptophan, and tyrosine, as amino acids or base acids. The specific formulation administered depends in part upon which stage 2-5 of renal disease the patient has. The invention further comprises methods of treatment of disorders associated with low serum albumin using the composition as an over-the-counter pill. The patient's serum albumin is tested on a periodic basis and the selected composition and dose are adjusted accordingly. And the invention comprises method of making α-leucine, α-valine, α-isoleucine, a-tyrosine and α-tryptophan in a multi-step process.
