Teit E. Johansen;Nikolaj Blom;Thomas Nordahl Petersen;Lars U. Wahlberg;Søren Brunak;Philip Kusk;Mette Grønborg
发明人:
Mette Grønborg,Philip Kusk,Nikolaj Blom,Thomas Nordahl Petersen,Teit E. Johansen,Søren Brunak,Lars U. Wahlberg
申请号：
US10594192
公开号：
US09845344B2
申请日:
2005.03.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.
