Teit E. Johansen;Nikolaj Blom;Soren Brunak;Thomas Nordahl Petersen;Lars U. Wahlberg;Philip Kusk;Mette Grønborg
发明人:
Mette Grønborg,Philip Kusk,Nikolaj Blom,Thomas Nordahl Petersen,Teit E. Johansen,Soren Brunak,Lars U. Wahlberg
申请号：
US13327423
公开号：
US20120184492A1
申请日:
2011.12.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.
