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DERIVATI HINOLINA ZA TRETIRANJE LATENTNE TUBERKULOZE
专利权人:
JANSSEN PHARMACEUTICA N.V.
发明人:
ANDRIES, Koenraad, Jozef, Lodewijk, Marcel,KOUL, Anil
申请号:
MEP9211
公开号:
ME01207B
申请日:
2005.12.08
申请国别(地区):
ME
年份:
2013
代理人:
摘要:
Use of a compound of formula (Ia) or (Ib) for the manufacture of a medicament for the treatment of latent tuberculosis, wherein the compound of formula (Ia) or (Ib) is a pharmaceutically acceptable salt, a quaternary amine, a N-oxide, a tautomeric form or a stereochemically isomeric form thereof wherein R<;SUP>;1 <;/SUP>;is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R<;SUP>;2 <;/SUP>;is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula ;R<;SUP>;3 <;/SUP>;is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is zero, 1, 2, 3 or 4; R<;SUP>;4 <;/SUP>;and R<;SUP>;5 <;/SUP>;each independently are hydrogen, alkyl or benzyl; or R<;SUP>;4 <;/SUP>;and R<;SUP>;5 <;/SUP>;may be taken together including the N to which they are attached; R<;SUP>;6 <;/SUP>;is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R<;SUP>;6 <;/SUP>;radicals may be taken together to form a bivalent radical -CH-CH-CH-CH-; r is 1, 2, 3, 4 or 5; R<;SUP>;7 <;/SUP>;is hydrogen, alkyl, Ar or Het; R<;SUP>;8 <;/SUP>;is hydrogen or alkyl; R<;SUP>;9 <;/SUP>;is oxo; or R<;SUP>;8 <;/SUP>;and R<;SUP>;9 <;/SUP>;together form the radical -N-CH-CH-.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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