CARDIOXYL PHARMACEUTICALS INC.;THE JOHNS HOPKINS UNIVERSITY;JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人:
申请号：
IL23827115
公开号：
IL238271A
申请日:
2015.04.14
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
