The Johns Hopkins University;Cardioxyl Pharmaceuticals, Inc.
发明人:
TOSCANO John P.,COHEN ANDREW D.,COURTNEY STEPHEN MARTIN,FROST LISA MARIE,KALISH VINCENT JACOB,BROOKFIELD FREDERICK ARTHUR,BROOKFIELD F
申请号：
PL12195124
公开号：
PL2586435T3
申请日:
2007.03.16
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
