Kyowa Hakko Kirin Co.; Limited;Kyowa Hakko Kirin Co., Limited;La Jolla Institute for Allergy and Immunology
发明人:
Granger, Steven W.,Ware, Carl F.,Kato, Shinichiro
申请号：
AU2007290570
公开号：
AU2007290570B2
申请日:
2007.08.24
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
Provided herein are antibodies, such as fully human antibodies, that immunospecificallybind to an hLIGHT polypeptide. Also provided are isolated nucleic acids encodingantibodies, such as fully human antibodies, that immunospecifically bind toa hLIGHT polypeptide. Further provided are vectors and host cells comprisingnucleic acids encoding antibodies, such as fully human antibodies, that immunospecificallybind to a hLIGHT polypeptide. Also provided are methods of making antibodies,such as fully human antibodies, that immunospecifically bind to a hLIGHT polypeptide.Also provided herein is a method of treating a hLIGHT- mediated disease in a subjectcomprising administering to the subject an antibody, such as a fully human antibody,that immunospecifically binds to a hLIGHT polypeptide. In preferred embodiments,that anti-hLIGHT antibodies provided herein will ameliorate, neutralize orotherwise inhibit hLIGHT biological activity
