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METHOD TO TREAT USING ANTAGONISTIC ANTI-hTNFSF13B HUMAN ANTIBODIES
专利权人:
Kristine Kay Kikly
发明人:
Kristine Kay Kikly
申请号:
US13444216
公开号:
US20120195904A1
申请日:
2012.04.11
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD=10−8M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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