A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR
- 专利权人:
- CEL-SCI CORPORATION
- 发明人:
- TALOR, EYAL
- 申请号：
- EP20050756247
- 公开号：
- EP1753452(B1)
- 申请日:
- 2005.06.03
- 申请国别(地区):
- 欧洲专利局
- 年份:
- 2015
- 代理人:
- 摘要：
A method for altering the CD4/CD8 ratio and the mononuclear cellular infiltrate into a tumor that results in significant modulation of the infiltrating immune cells shown by a decrease in CD8+ T cells and a significant increase in tumor infiltrating CD4+ T cells. A dose of 800 IU/day as IL-2 for 5 days per week for 3 weeks of a Leukocyte Interleukin Injection (LI) being a serum-free and mitogen-free mixture comprised of specific ratios of cytokines IL-1beta, TNF-alpha, IFN-gamma and GM-CSF to Interleukin 2 (IL-2) resulted in a paradigm shift. The paradigm shift is defined as a marked CD4+ T cell infiltrate and a clear and specific change in the density and localization of antigen presenting cells such as dendritic cells and inflammatory cells, particularly neutrophils in cancer nests.
- 来源网站：
- 中国工程科技知识中心
