A pharmaceutical composition as a solid oral dosage form is described, comprising: i) a combination of two pharmacological active principles, dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, wherein: - the organic or inorganic base is selected in the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide - the organic or inorganic acid is selected in the group: hydrochloric, hydrobromic, phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic, maleic, succinic, citrie, L-tartaric, lactic, malonic, aspartic, glutamic； ii) microcrystalline cellulose as a filler； iii) a binder slected in the group: maize starch, pre-gelatinised maize starch, hypromellose or their mixtures； ix) pharmaceutically acceptable excipients.描述一種呈固體口服劑型的醫藥組成物，其係包含：i)兩種藥理活性成分，右旋酮洛芬(DEXKETOPROFEN)與有機或無機鹼之鹽及特拉嗎竇(TRAMADOL)與有機或無機酸之鹽的組合，其中：- 該有機或無機鹼係選自於下述組群：胺丁三醇(trometamol)、三甲胺、二甲胺、乙胺、三乙胺、二乙胺、L-離胺酸、L-精胺酸、二乙醇胺、氫氧化鈉、氫氧化鈣；- 該有機或無機酸係選自於下述組群：氫氯酸、氫溴酸、磷酸、硫酸、甲烷磺酸、苯磺酸、甲苯磺酸、乙酸、丙酸、蘋果酸、順丁烯二酸、丁二酸、檸檬酸、L-酒石酸、乳酸、丙二酸、天冬酸、麩胺酸；ii)微晶纖維素作為填充劑；iii)選自於下述該組群的一黏結劑：玉米澱粉、預膠化玉米澱粉、羥丙甲纖維素或其混合物；iv)醫藥上可接受之賦形劑。
