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Pharmaceutical compositions containing dexketoprofen and tramadol
专利权人:
LABORATORIOS MENARINI SA
发明人:
KOHL TOBIAS,SCHMITZ REINHARD
申请号:
AP2015008616
公开号:
AP2015008616A0
申请日:
2014.02.06
申请国别(地区):
AP
年份:
2015
代理人:
摘要:
A pharmaceutical composition as a solid oral dosage form is described, comprising: i) a combination of two pharmacological active principles, dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, wherein: the organic or inorganic base is selected in the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide the organic or inorganic acid is selected in the group: hydrochloric, hydrobromic, phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic, maleic, succinic, citric, L-tartaric, lactic, malonic, aspartic, glutamic; ii) microcrystalline cellulose as a filler; iii) a binder selected in the group: maize starch, pre-gelatinised maize starch, hypromellose or their mixtures; iv) pharmaceutically acceptable excipients.
来源网站:
中国工程科技知识中心
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