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Pharmaceutical compositions containing dexketoprofen and tramadol
专利权人:
Laboratorios Menarini SA
发明人:
Schmitz, Reinhard,Kohl, Tobias
申请号:
AU2014218110
公开号:
AU2014218110A1
申请日:
2014.02.06
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
A pharmaceutical composition as a solid oral dosage form is described, comprising: i) a combination of two pharmacological active principles, dexketoprofen salt with an organic or inorganic base and tramadol salt with an organic or inorganic acid, wherein: - the organic or inorganic base is selected in the group: trometamol, trimethylamine, dimethylamine, ethylamine, triethylamine, diethylamine, L-lysine, L-arginine, diethanolamine, sodium hydroxide, calcium hydroxide - the organic or inorganic acid is selected in the group: hydrochloric, hydrobromic, phosphoric, sulfuric, methanesulfonic, benzenesulfonic, toluenesulfonic, acetic, propionic, malic, maleic, succinic, citric, L-tartaric, lactic, malonic, aspartic, glutamic; ii) microcrystalline cellulose as a filler; iii) a binder selected in the group: maize starch,pre-gelatinised maize starch, hypromellose or their mixtures; iv) pharmaceutically acceptable excipients.
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