刺激和擴大T細胞的組合物和方法

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

ZHAO, Yangbing,LIU, Xiaojun,JUNE, Carl H.

申请号：

HK18102827.5

公开号：

HK1243334A

申请日:

2018.02.27

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the cultured T cells expand at least 10 fold. The invention further includes an expanded population of T cells, compositions comprising the cells and methods of treatment.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/