PROBLEM TO BE SOLVED: To track temperature-induced glycolysis in noninvasive glucose measurement.SOLUTION: A noninvasive glucose measurement apparatus according to an embodiment comprises: means for adjusting the temperature of a localized reflectance optical probe which is made contact with skin to temperature substantially different from the normal temperature of the skin means for selecting a time window in which the effect of tissue-probe adaptability for a signal can be suppressed to a minimal level means for measuring the change of a localized reflected light signal in response to various distances between a light source and a detector, various wavelengths, various lengths of contact time, for a given period of time after the probe is made contact with the skin means for calculating the change of a function related to the effect of heat stimulation in response to the change of light absorption due to hemoglobin means for calculating the change of a function related to the effect of heat stimulation in response to the change of light attenuation means for deriving a calibration relation between a combination of functions derived from a localized reflectance signal and the glucose concentration and means for using the calibration relation to predict the glucose concentration within the subject during the subsequent time.COPYRIGHT: (C)2015,JPO&INPIT【課題】 グルコースの非侵襲性測定において温度誘発糖分解を追跡すること。【解決手段】 実施形態に係るグルコースの非侵襲性測定装置は、皮膚に接触された局在反射率光学プローブの温度を皮膚の正常温度と実質的に異なる温度に調節する手段と、信号に対する組織-プローブ適応性の影響が最小限に抑えられる時間ウインドウを選択する手段と、様々な光源-検出器間距離、様々な波長、様々な接触時間に対する局在反射光信号の変化を、プローブを皮膚に接触させてから一定時間の間測定する手段と、ヘモグロビンによる光吸収の変化に対する熱刺激の影響に関連する関数の変化を計算する手段と、光減衰の変化に対する熱刺激の効果に関連する関数の変化を計算する手段と、局在反射率の信号から導き出された関数の組み合わせと、グルコース濃度との間の較正関係を導き出す手段と、後続の時間での被検体中のグルコース濃度を予測するために較正関係を使用する手段とを具備する。【選択図】図1
