A device (1) for treatments of endoscopic resection/removal of tissues, includes: a handpiece apt to be held by an user; an external tubular element (3) having a proximal end, a distal end and a cutting aperture disposed at the distal end; an internal tubular element (4) apt to be pivotally housed in the external tubular element (3) and having a proximal end, a distal end and a cutting tip at its distal end; guide element (5) for rotating and/or oscillating the internal tubular element (4) with respect to the external tubular element (3); the guide element including an electric motor. At least one between the handpiece (2) and the guide element (5) is disposable.