A device (1) for treatments of endoscopic resection/removal of tissues, includes: a handpiece apt to be held by an user an external tubular element (3) having a proximal end, a distal end and a cutting aperture disposed at the distal end an internal tubular element (4) apt to be pivotally housed in the external tubular element (3) and having a proximal end, a distal end and a cutting tip at its distal end guide element (5) for rotating and/or oscillating the internal tubular element (4) with respect to the external tubular element (3) the guide element including an electric motor. At least one between the handpiece (2) and the guide element (5) is disposable.