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새로운 항균 화합물, 이들의 합성 및 포유류 감염 치료를 위한 이들의 용도
专利权人:
发明人:
묄만, 우테,마카로프, 바딤,스테바르트, 티., 콜레
申请号:
KR1020107003264
公开号:
KR1015880640000B1
申请日:
2008.06.25
申请国别(地区):
KR
年份:
2016
代理人:
摘要:
The present invention relates to their use for new antimicrobial compounds, their synthesis and treating mammalian infections. The present invention is as a potential new tuberculosis drugs to overcome problems concerning resistance and drug intolerance for the purpose of creation of a new compound having an activity for mycobacteria. This object is solved by providing a compound of formula I. R < I > Wherein, R 1 and R 2 are, independently of each other, NO 2 , NR 7 R 8 , NHOR 9 , COOR 9 , CN, CONR 10 R 11 , CHO, F, Cl, Br, SO 2 NR 12 R 13 , lower alkoxy, OCF 3 , mono-, di- or trifluoromethyl R 3 and R 4 are, independently, H, 1 to 3 chain members, saturated or unsaturated, linear or branched aliphatic radical having a, F, Cl , Br, lower alkoxy R 5 is H, saturated with dog 1 to 7 chain members, or unsaturated, halogenated or non-halogenated, linear or branched aliphatic radical R 6 is radical: , where , X is a saturated or unsaturated, halogenated or non having 1 to 5 chain members - or a halogenated, linear or branched aliphatic radical, or R 5 and R 6 together are a divalent radical: denotes a wherein n is 1 to 4 ego R 7 to R 13 , independently of each other, H, or 1 saturated one to having 5 chain members or unsaturated, halogenated or non-halogenated, linear or It branched aliphatic radical, phenyl, benzyl, or R 7 and R 8 , together, R 10 and R 11 together, R 12 and R 13 is from 1 to 7 straight or branched chain aliphatic having two members with a represent a radical R 14 and R 15 are, independently, H, 1 to 5 of the chain member of a linear or branched aliphatic radical having a, F, Cl, Br, NO the 2 , NH 2 , CF 3본 발명은, 새로운 항균 화합물, 이들의 합성 및 포유류 감염 치료를 위한 이들의 용도에 관한 것이다. 본 발명은, 내성 및 약물 불내성에 관한 문제를 극복하기 위한 가능성 있는 새로운 결핵 약물로서 마이코박테리아에 대한 활성을 갖는 새로운 화합물의 생성을 목적으로 한다. 이러한 목적은 하기 화학식 I의 화합물을 제공함으로써 해결된다.<화학식 I> 상기 식에서, R1 및 R2는, 서로 독립적으로, NO2, NR7R8
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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