SUBSTRATS RECONNUS PAR UNE PROTÉINE D'ACTIVATION DES FIBROBLASTES (FAP) ET LEURS MÉTHODES D'UTILISATION

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专利权人:

F. Hoffmann-La Roche AG

发明人:

申请号：

EP18781501.4

公开号：

EP3606939A1

申请日:

2018.04.04

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines comprising the nucleic acids, and kits comprising the construct. Further provided are methods of detecting FAP using the construct via FRET.

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