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SUBSTRATES RECOGNIZED BY FIBROBLAST ACTIVATION PROTEIN (FAP) AND METHODS OF USING THE SAME
专利权人:
INC.;GENENTECH
发明人:
Travis William BAINBRIDGE,James Andrew ERNST,Junichiro SONODA
申请号:
US16589740
公开号:
US20200055896A1
申请日:
2019.10.01
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines comprising the nucleic acids, and kits comprising the construct. Further provided are methods of detecting FAP using the construct via FRET.
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