The invention provides polynucleotides and polypeptides encoded therefromhaving advantageous properties, including an ability to induce an immuneresponse to flaviviruses. The polypeptides and polynucleotides of theinvention are useful in methods of inducing immune response againstflaviviruses, including dengue viruses. Compositions and methods for utilizingpolynucleotides and polypeptides of the invention are also provided.