PROBLEM TO BE SOLVED: To find a novel factor capable of suppressing a decline in macrophage function, and to detect diseases associated with a decline in macrophage function such as age-related diseases caused by age-related immune function decline and accumulation of senescent cells including aging stem cells, or To provide a formulation effective for the treatment and / or prevention of symptoms. SOLUTION: 1 selected from the group consisting of IL-1α, IL-1β, IL-8, GM-CSF, TNF-α, IFN-γ, MMP-1, MMP-2, PAI-2, and MIF. A macrophage hypofunction suppressing agent, comprising a substance that inhibits the activity or expression of one or more cell senescence-related secretory phenomenon (SASP) factors as an active ingredient. [Selection diagram] None【課題】マクロファージの機能低下を抑制できる新たな因子を見出し、加齢に伴う免疫機能低下や老化幹細胞を含む老化細胞の蓄積に起因する加齢性疾患などのマクロファージの機能低下に関連する疾患又は症状の治療及び／又は予防に有効な製剤を提供すること。【解決手段】IL-1α、IL-1β、IL-8、GM-CSF、TNF-α、IFN-γ、MMP-1、MMP-2、PAI-2、及びMIFから成る群より選択される１種又は２種以上の細胞老化関連分泌現象(SASP)因子の活性又は発現を阻害する物質を有効成分として含有する、マクロファージの機能低下抑制剤。【選択図】なし
