Injection device having a needle protection system, said injection device having a dispensing needle (10) provided with a dispensing orifice (11), said protection system having a removable needle guard (20) which is designed to be arranged on said needle (10), in the non-dispensing position, in order to protect and isolate said dispensing orifice (11) of said needle (10), said needle guard (20) having an insulating part (21) made of flexible material, said dispensing orifice (11) of the needle (10) being stuck in said insulating part (21) in the non-dispensing position, said needle guard (20) having at least one radial projection (25) towards the outside, said protection system having an external cap (30) provided with gripping means (35, 35, 36 38 300) which are designed to cooperate with said at least one radial projection (25) of said needle guard (20), in such a way that a movement of said external cap (30) in the longitudinal direction of said needle (10) away from said dispensing orifice (11) draws said needle guard (20) from its non-dispensing position, said at least one radial projection (25) being arranged at the distal axial end of said needle guard (20), said at least one radial projection (25) being formed on a rigid external structure (28) of said needle guard (20).Dispositif dinjection comportant un système de protection daiguille, ledit dispositif dinjection comportant une aiguille de distribution (10) pourvue dun orifice de distribution (11), ledit système de protection comportant un protège-aiguille amovible (20) adapté à être disposé, en position de non- distribution, sur ladite aiguille (10) pour protéger et isoler ledit orifice de distribution (11) de ladite aiguille (10), ledit protège-aiguille (20) comportant une partie disolation (21) en matériau souple, ledit orifice de distribution (11) de laiguille (10) étant piqué dans ladite partie disolation (21) en position de non-distribution, ledit protège-aiguille (10) comportant au moins une project