Philipp KLAHN,Mark BROENSTRUP,Verena FETZ,Wera COLLISI,Katrin I MOHR,Stephan HUETTEL,Werner TEGGE
申请号：
US16637257
公开号：
US20200239426A1
申请日:
2018.08.08
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.
