VIEIRA, Eric,JAESCHKE, Georg,RICCI, Antonio,RUEHER, Daniel,BIEMANS, Barbara,GUBA, Wolfgang
申请号：
MA38885
公开号：
MA38885A1
申请日:
2014.09.22
申请国别(地区):
MA
年份:
2017
代理人:
摘要：
The invention relates to a compound of formula I, comprising N or c-r1 '.G represents 5 or 6 aromatic or heteroaromatic cores containing 0, 1, 2 or 3 heteroatoms, and is selected from phenyl, pyrazinyl, pyrimidinyl, thiophene, thiazolyl, pyrazolyl or thiadiazole groups in different positions, a. Free halogenated, low alkyl, low alkoxy, low alkoxy or 1, 2 or 3 substituents substituted by halogenated or NRR；R and R are independent of another hydrogen atom or lower alkyl group, or they can form a saturated heterocyclic group together with N atom, which can contain another oxygen atom or n ("lower alkyl") or n ("lower alkyl").R1 is a halogen substituted hydrogen atom, halogen atom or low-level alkyl group；R1 is a hydrogen atom, halogen atom or lower alkyl substituted by halogen；R2 is hydrogen atom or lower alkyl, lower alkoxy, cycloalkyl or heterocycloalkyl；Or R2 can be formed in group G with the closest carbon atom ("ia").A for - CH2,-CH2CH2 or "(CH3)) - 2；R3 is a phenyl or pyridyl group, and N atom may be in different positions in the pyridyl group；Or a pharmaceutically acceptable salt or acid addition salt thereof, racemic mixture thereof or its corresponding isomer and / or optical and / or stereoisomer thereof. It was suddenly found that the compound of general formula I is the orthoisomeric modulator ("PMP") of metabotropic glutamate 4 receptor (mglu4),For Parkinson's disease and anxietyVomiting, obsessive-compulsive dementia, autism, neuroprotection and treatment of cancer, depression and type 2 diabetes.La présente invention porte sur des composés de formule i dans laquelle y représente n ou c-r1' ； g représente un noyau aromatique ou hétéroaromatique à 5 ou 6 chaînons contenant 0, 1, 2 ou 3 hétéroatomes, choisi dans le groupe constitué par les noyaux phényle, pyridinyle à différentes positions de n, imidazolyle, pyrazinyle, pyrimidinyle, thiophényle, thiazolyle, pyrazolyle ou thiadiazolyle, qui sont éventuellement substitués par 1, 2 ou 3 substituants, choisi
