Shelley Allen,Mark Laurence Boys,Mark J. Chicarelli,Jay Bradford Fell,John P. Fischer,John Gaudino,Erik James Hicken,Ronald Jay Hinklin,Christopher F. Kraser,Ellen Laird,John E. Robinson,Tony P. Tang
申请号：
US16890663
公开号：
US20200291039A1
申请日:
2020.06.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compounds of Formula I:and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
